Silver-catalyzed synthesis of ß-fluorovinylphosphonates by phosphonofluorination of aromatic alkynes.
Beilstein J Org Chem
; 16: 3086-3092, 2020.
Article
em En
| MEDLINE
| ID: mdl-33414856
ABSTRACT
A silver-catalyzed three-component reaction involving alkynes, Selectfluor®, and diethyl phosphite was employed for the one-pot formation of C(sp2)-F and C(sp2)-P bonds to provide an efficient access to ß-fluorovinylphosphonates in a highly regio- and stereoselective manner under mild reaction conditions. This reaction is operationally simple and offers an excellent functional group tolerance as well as a broad substrate scope that includes both terminal and internal alkynes. The reaction proceeded through the oxidative generation of a P-centered radical and subsequent fluorine atom transfer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Beilstein J Org Chem
Ano de publicação:
2020
Tipo de documento:
Article