Targeting STAT3 by a small molecule suppresses pancreatic cancer progression.

Chen, Huang; Bian, Aiwu; Yang, Lian-Fang; Yin, Xuan; Wang, Jie; Ti, Chaowen; Miao, Ying; Peng, Shihong; Xu, Shifen; Liu, Mingyao; Qiu, Wen-Wei; Yi, Zhengfang

Chen, Huang; Bian, Aiwu; Yang, Lian-Fang; Yin, Xuan; Wang, Jie; Ti, Chaowen; Miao, Ying; Peng, Shihong; Xu, Shifen; Liu, Mingyao; Qiu, Wen-Wei; Yi, Zhengfang.

Afiliação

Chen H; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Bian A; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Yang LF; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.
Yin X; Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wang J; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China.
Ti C; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Miao Y; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Peng S; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China.
Xu S; Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Liu M; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. myliu@bio.ecnu.edu.
Qiu WW; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, China. wwqiu@chem.ecnu.edu.cn.
Yi Z; East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China. zfyi@bio.ecnu.edu.c

Oncogene ; 40(8): 1440-1457, 2021 02.

Article em En | MEDLINE | ID: mdl-33420372

Assuntos

Neoplasias Pancreáticas/tratamento farmacológico; Fator de Transcrição STAT3/genética; Bibliotecas de Moléculas Pequenas/farmacologia; Animais; Apoptose/efeitos dos fármacos; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Receptores ErbB/genética; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Humanos; Camundongos; NF-kappa B/genética; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/patologia; Transdução de Sinais/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto; Domínios de Homologia de src/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Fator de Transcrição STAT3 / Bibliotecas de Moléculas Pequenas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Oncogene Assunto da revista: BIOLOGIA MOLECULAR / NEOPLASIAS Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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