Inhibition of TGFß-activated kinase 1 promotes inflammation-resolving microglial/macrophage responses and recovery after stroke in ovariectomized female mice.

Liu, Yaan; Li, Sicheng; Wang, Rongrong; Pu, Hongjian; Zhao, Yongfang; Ye, Qing; Shi, Yejie

Liu, Yaan; Li, Sicheng; Wang, Rongrong; Pu, Hongjian; Zhao, Yongfang; Ye, Qing; Shi, Yejie.

Afiliação

Liu Y; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, United States of America.
Li S; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, United States of America.
Wang R; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, United States of America.
Pu H; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, United States of America.
Zhao Y; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, United States of America.
Ye Q; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, United States of America.
Shi Y; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, United States of America. Electronic address: y.shi@pitt.edu.

Neurobiol Dis ; 151: 105257, 2021 04.

Article em En | MEDLINE | ID: mdl-33434616

Assuntos

Inibidores Enzimáticos/farmacologia; Infarto da Artéria Cerebral Média/metabolismo; MAP Quinase Quinase Quinases/antagonistas & inibidores; Macrófagos/metabolismo; Microglia/metabolismo; Recuperação de Função Fisiológica/efeitos dos fármacos; Animais; Feminino; Inflamação/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Ovariectomia; Zearalenona/análogos & derivados; Zearalenona/farmacologia

Palavras-chave

5Z-7-Oxozeaenol; Inflammation; MAP3K7; Ovariectomized mice; TAK1; Transient focal cerebral ischemia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Microglia / Recuperação de Função Fisiológica / Infarto da Artéria Cerebral Média / MAP Quinase Quinase Quinases / Inibidores Enzimáticos / Macrófagos Limite: Animals Idioma: En Revista: Neurobiol Dis Assunto da revista: NEUROLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos

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