GPR55 Receptor Activation by the <i>N</i>-Acyl Dopamine Family Lipids Induces Apoptosis in Cancer Cells via the Nitric Oxide Synthase (nNOS) Over-Stimulation.

Akimov, Mikhail G; Gamisonia, Alina M; Dudina, Polina V; Gretskaya, Natalia M; Gaydaryova, Anastasia A; Kuznetsov, Andrey S; Zinchenko, Galina N; Bezuglov, Vladimir V

GPR55 Receptor Activation by the N-Acyl Dopamine Family Lipids Induces Apoptosis in Cancer Cells via the Nitric Oxide Synthase (nNOS) Over-Stimulation.

Akimov, Mikhail G; Gamisonia, Alina M; Dudina, Polina V; Gretskaya, Natalia M; Gaydaryova, Anastasia A; Kuznetsov, Andrey S; Zinchenko, Galina N; Bezuglov, Vladimir V.

Afiliação

Akimov MG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia.
Gamisonia AM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia.
Dudina PV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia.
Gretskaya NM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia.
Gaydaryova AA; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia.
Kuznetsov AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia.
Zinchenko GN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia.
Bezuglov VV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia.

Int J Mol Sci ; 22(2)2021 Jan 09.

Article em En | MEDLINE | ID: mdl-33435517

Assuntos

Antineoplásicos/farmacologia; Agonistas de Receptores de Canabinoides/farmacologia; Dopamina/análogos & derivados; Ativadores de Enzimas/farmacologia; Óxido Nítrico Sintase Tipo I/metabolismo; Receptores de Canabinoides/metabolismo; Animais; Antineoplásicos/química; Apoptose/efeitos dos fármacos; Agonistas de Receptores de Canabinoides/química; Linhagem Celular Tumoral; Dopamina/química; Dopamina/farmacologia; Ativadores de Enzimas/química; Ácidos Graxos/química; Ácidos Graxos/farmacologia; Humanos; Simulação de Acoplamento Molecular; Neoplasias/tratamento farmacológico; Neoplasias/metabolismo; Células PC12; Ratos

Palavras-chave

GPR55; N-acyldopamines; N-acyldopamines cytotoxicity; cancer cell apoptosis; endocannabinoids; nitric oxide synthase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dopamina / Ativadores de Enzimas / Receptores de Canabinoides / Óxido Nítrico Sintase Tipo I / Agonistas de Receptores de Canabinoides / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Federação Russa País de publicação: Suíça

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