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Suboptimal vaccination coverage of recommended vaccines among French children with recurrent autoinflammatory fever syndromes: a study from the Juvenile Inflammatory Rheumatism cohort.
Rollet-Cohen, Virginie; Mirete, Justine; Dingulu, Glory; Hofer, François; Hofer, Michael; Woerner, Andreas; Dommergues, Marie-Aliette; Hentgen, Véronique.
Afiliação
  • Rollet-Cohen V; Department of General Pediatrics, Versailles Hospital, 177 rue de Versailles, 78150, Le Chesnay, Paris, France. virginierollet11@gmail.com.
  • Mirete J; Department of General Pediatrics, Versailles Hospital, 177 rue de Versailles, 78150, Le Chesnay, Paris, France.
  • Dingulu G; Reference Center for Autoinflammatory Diseases and Amyloidosis, Versailles Hospital-CEREMAIA, 78150, Le Chesnay, Paris, France.
  • Hofer F; Fondation Rhumatismes-Enfants-Suisse, 1163, Etoy, Switzerland.
  • Hofer M; Paediatric Rheumatology Western Switzerland, Centre Hospitalier Universitaire Vaudois (CHUV), 1011, Lausanne, Switzerland.
  • Woerner A; Hospital Universitaire Genève (HUG), 1206, Geneva, Switzerland.
  • Dommergues MA; Paediatric Rheumatology, University of Basel, University Children's Hospital, 4031, Basel, Switzerland.
  • Hentgen V; Department of General Pediatrics, Versailles Hospital, 177 rue de Versailles, 78150, Le Chesnay, Paris, France.
Clin Rheumatol ; 40(7): 2855-2864, 2021 Jul.
Article em En | MEDLINE | ID: mdl-33439385
INTRODUCTION/OBJECTIVES: To determine vaccination coverage among a French cohort of children with recurrent autoinflammatory fever syndromes (RFS). METHOD: All RFS children aged 2 to 19 years from the Juvenile Inflammatory Rheumatism cohort and followed at the French Reference Center for Autoinflammatory Diseases, Versailles Hospital, were included in our observational study. Immunisation status at ages 2, 7 and 15 years and at the last outpatient visit was evaluated according to the standard French vaccine schedule and recommended supplementary vaccines for patients with immunosuppressive therapy. RESULTS: Of 200 patients, 90 (45%) had periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome; 52 (26%) had familial Mediterranean fever and 50 (25%) had undefined recurrent fever. Complete immunisation as per the standard schedule was obtained by 32% of patients at 2 years, 28% at 7 years, 6% at 15 years and 44% at the last outpatient visit. Similar or higher coverage was obtained by the last outpatient visit for most vaccines, compared to immunisation coverage at 2 years: pneumococcus (91% vs 88%), diphtheria tetanus poliomyelitis (82% vs 86%), hepatitis B (79% vs 69%) and measles, mumps, rubella (91% vs 50%). No patients with immunosuppressive therapy (n = 14) were up to date for all supplementary immunisations recommended for them. CONCLUSION: Vaccination coverage for RFS children is suboptimal, especially for infants who present with recurrent febrile episodes. The initial vaccination delay is partially corrected through specialist follow-up in later years. Coverage according to the supplementary vaccine recommendations for immunosuppressed patients is poor. Key Points • Vaccination coverage for RFS children is suboptimal, especially at 2 years of age which is likely due to the prevalence of early recurrent febrile symptoms. • The initial vaccination delay is partially recovered during later follow-up at an expert rheumatology center. • Specific recommendations are particularly difficult to apply to patients on immunosuppressive therapy.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre Reumática / Estomatite Aftosa / Vacinas / Faringite / Linfadenite Tipo de estudo: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Revista: Clin Rheumatol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França País de publicação: Alemanha

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Febre Reumática / Estomatite Aftosa / Vacinas / Faringite / Linfadenite Tipo de estudo: Etiology_studies / Guideline / Observational_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Humans / Infant Idioma: En Revista: Clin Rheumatol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: França País de publicação: Alemanha