Exosome-based <i>Ldlr</i> gene therapy for familial hypercholesterolemia in a mouse model.

Li, Zhelong; Zhao, Ping; Zhang, Yajun; Wang, Jia; Wang, Chen; Liu, Yunnan; Yang, Guodong; Yuan, Lijun

Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model.

Li, Zhelong; Zhao, Ping; Zhang, Yajun; Wang, Jia; Wang, Chen; Liu, Yunnan; Yang, Guodong; Yuan, Lijun.

Afiliação

Li Z; Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.
Zhao P; The State Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, People's Republic of China.
Zhang Y; Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.
Wang J; Department of Ultrasound Diagnostics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Wang C; Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.
Liu Y; Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.
Yang G; The State Laboratory of Cancer Biology, Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, People's Republic of China.
Yuan L; Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an, People's Republic of China.

Theranostics ; 11(6): 2953-2965, 2021.

Article em En | MEDLINE | ID: mdl-33456582

Assuntos

Exossomos/genética; Hiperlipoproteinemia Tipo II/genética; Hiperlipoproteinemia Tipo II/terapia; Receptores de LDL/genética; Animais; Aterosclerose/genética; Aterosclerose/metabolismo; Aterosclerose/terapia; Linhagem Celular; Modelos Animais de Doenças; Terapia Genética/métodos; Células HEK293; Humanos; Hiperlipoproteinemia Tipo II/metabolismo; Fígado/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; Placa Aterosclerótica/genética; Placa Aterosclerótica/metabolismo; Placa Aterosclerótica/terapia; RNA Mensageiro/genética; Receptores de LDL/metabolismo

Palavras-chave

atherosclerosis; exosomes; familial hypercholesterolemia; gene therapy; low-density lipoprotein receptor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de LDL / Exossomos / Hiperlipoproteinemia Tipo II Limite: Animals / Humans Idioma: En Revista: Theranostics Ano de publicação: 2021 Tipo de documento: Article País de publicação: Austrália

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