In Situ 3D Label-Free Contactless Bioprinting of Cells through Diamagnetophoresis.
ACS Biomater Sci Eng
; 2(12): 2133-2138, 2016 Dec 12.
Article
em En
| MEDLINE
| ID: mdl-33465889
ABSTRACT
Using whole blood, we demonstrate the first realization of a novel macroscale, contactless, label-free method to print in situ three-dimensional (3D) cell assemblies of different morphologies and sizes. This novel bioprinting method does not use nozzles that can contaminate the cell suspension, or to which cells can adhere. Instead, we utilize the intrinsic diamagnetic properties of whole blood cells to magnetically manipulate them in situ in a nontoxic paramagnetic medium, creating (a) rectangular bar, (b) three-pointed star, and (c) spheroids of varying sizes. We envision the technique to be transferable to other cell lines, with potential applications in tissue engineering and drug screening.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
ACS Biomater Sci Eng
Ano de publicação:
2016
Tipo de documento:
Article
País de afiliação:
Canadá