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Multilocus Sequence Typing of Clinical Isolates of Cryptococcus from India.
Xess, Immaculata; Pandey, Mragnayani; Dabas, Yubhisha; Agarwal, Reshu; Das, Shukla; Srivastava, Padma M V; Thakur, Rajeev; Sharma, Shyama; Mani, Prashant; Biswas, Ashutosh; Bhowmik, Dipankar; Das, Bimal K; Singh, Rakesh; Panda, Preetilata; Singh, Gagandeep; Phukan, A C; Yhome, Margaret; Valsan, Chithra; Kindo, Anupma Jyoti.
Afiliação
  • Xess I; Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, Delhi, 110029, India. immaxess@gmail.com.
  • Pandey M; Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, Delhi, 110029, India.
  • Dabas Y; Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, Delhi, 110029, India.
  • Agarwal R; Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, Delhi, 110029, India.
  • Das S; Department of Microbiology, University College of Medical Sciences (UCMS) & Guru TegBahadur (GTB) Hospital, New Delhi, Delhi, India.
  • Srivastava PMV; Department of Neurology, All India Institute of Medical Sciences (AIIMS), New Delhi, Delhi, India.
  • Thakur R; Department of Microbiology, Institute of Human Behavior& Allied Sciences (IHBAS), Delhi, India.
  • Sharma S; Department of Microbiology, University College of Medical Sciences (UCMS) & Guru TegBahadur (GTB) Hospital, New Delhi, Delhi, India.
  • Mani P; Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, Delhi, 110029, India.
  • Biswas A; Department of Medicine, All India Institute of Medical Sciences (AIIMS), New Delhi, Delhi, India.
  • Bhowmik D; Department of Nephrology, All India Institute of Medical Sciences (AIIMS), New Delhi, Delhi, India.
  • Das BK; Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, Delhi, 110029, India.
  • Singh R; Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.
  • Panda P; Department of Microbiology, Maharaja Krishna Chandra Gajapati (MKCG) Medical College & Hospital, Brahmapur, Odisha, India.
  • Singh G; Department of Microbiology, All India Institute of Medical Sciences (AIIMS), New Delhi, Delhi, 110029, India.
  • Phukan AC; Department of Microbiology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, Meghalaya, India.
  • Yhome M; Department of Microbiology, Naga Hospital Authority Kohima (NHAK), Kohima, Nagaland, India.
  • Valsan C; Department of Microbiology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, India.
  • Kindo AJ; Department of Microbiology, Sri Ramachandra Medical College and Research Institute (SRMC & RI), Chennai, Tamil Nadu, India.
Mycopathologia ; 186(2): 199-211, 2021 May.
Article em En | MEDLINE | ID: mdl-33469844
ABSTRACT
Cryptococcosis is a life-threatening infection caused by Cryptococcus neoformans and C. gattii species complex. In the present study, to understand the molecular epidemiology of 208 clinical isolates of Cryptococcus from different parts of India, multilocus sequence typing (MLST) using ISHAM MLST consensus scheme for C. neoformans/C. gattii species complex was used. MLST analysis yielded a total of 10 Sequence Types (STs)-7 STs for C. neoformans and 3 for C. gattii species complex. The majority of isolates identified as C. neoformans belonged to molecular type VNI with predominant STs 31 and 93. Only 3 isolates of C. gattii species complex were obtained, belonging to ST58 and ST215 of VGI and ST69 of VGIV. Phylogenetic analysis revealed less diversity among the clinical Indian isolates compared to the global MLST database. No association between prevalent STs and HIV status, geographical origin or minimum inhibitory concentration (MIC) could be established.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Criptococose / Cryptococcus neoformans / Cryptococcus gattii Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Mycopathologia Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Criptococose / Cryptococcus neoformans / Cryptococcus gattii Limite: Humans País/Região como assunto: Asia Idioma: En Revista: Mycopathologia Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Índia