Multilocus Sequence Typing of Clinical Isolates of Cryptococcus from India.
Mycopathologia
; 186(2): 199-211, 2021 May.
Article
em En
| MEDLINE
| ID: mdl-33469844
ABSTRACT
Cryptococcosis is a life-threatening infection caused by Cryptococcus neoformans and C. gattii species complex. In the present study, to understand the molecular epidemiology of 208 clinical isolates of Cryptococcus from different parts of India, multilocus sequence typing (MLST) using ISHAM MLST consensus scheme for C. neoformans/C. gattii species complex was used. MLST analysis yielded a total of 10 Sequence Types (STs)-7 STs for C. neoformans and 3 for C. gattii species complex. The majority of isolates identified as C. neoformans belonged to molecular type VNI with predominant STs 31 and 93. Only 3 isolates of C. gattii species complex were obtained, belonging to ST58 and ST215 of VGI and ST69 of VGIV. Phylogenetic analysis revealed less diversity among the clinical Indian isolates compared to the global MLST database. No association between prevalent STs and HIV status, geographical origin or minimum inhibitory concentration (MIC) could be established.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Criptococose
/
Cryptococcus neoformans
/
Cryptococcus gattii
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Mycopathologia
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Índia