TRIC-A regulates intracellular Ca2+ homeostasis in cardiomyocytes.
Pflugers Arch
; 473(3): 547-556, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33474637
ABSTRACT
Trimeric intracellular cation (TRIC) channels have been identified as monovalent cation channels that are located in the ER/SR membrane. Two isoforms discovered in mammals are TRIC-A (TMEM38a) and TRIC-B (TMEM38b). TRIC-B ubiquitously expresses in all tissues, and TRIC-B-/- mice is lethal at the neonatal stage. TRIC-A mainly expresses in excitable cells. TRIC-A-/- mice survive normally but show abnormal SR Ca2+ handling in both skeletal and cardiac muscle cells. Importantly, TRIC-A mutations have been identified in human patients with stress-induced arrhythmia. In the past decade, important discoveries have been made to understand the structure and function of TRIC channels, especially its role in regulating intracellular Ca2+ homeostasis. In this review article, we focus on the potential roles of TRIC-A in regulating cardiac function, particularly its effects on intracellular Ca2+ signaling of cardiomyocytes and discuss the current knowledge gaps.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinalização do Cálcio
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Miócitos Cardíacos
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Homeostase
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Canais Iônicos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Pflugers Arch
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos