First-in-human safety, tolerability, and pharmacokinetics of ammoxetine in healthy subjects: a randomized, double-blind, placebo-controlled phase I study.

Shen, Qi; Hu, Chao; Miao, Jia; Chen, Junxia; Peng, Yueying; Pan, Tingting; He, Xiaolin; Yuan, Jing; Ni, Shaonan; Wang, Yongsheng; Luo, Zhu

Shen, Qi; Hu, Chao; Miao, Jia; Chen, Junxia; Peng, Yueying; Pan, Tingting; He, Xiaolin; Yuan, Jing; Ni, Shaonan; Wang, Yongsheng; Luo, Zhu.

Afiliação

Shen Q; GCP Center/ Institute of Drug Clinical Trials, West China Hospital of Sichuan University, Sichuan, China.
Hu C; GCP Center/ Institute of Drug Clinical Trials, West China Hospital of Sichuan University, Sichuan, China.
Miao J; GCP Center/ Institute of Drug Clinical Trials, West China Hospital of Sichuan University, Sichuan, China.
Chen J; Department of Medicine, CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd., Hebei, China.
Peng Y; Department of Medicine, CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd., Hebei, China.
Pan T; Department of Project Management, CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd., Hebei, China.
He X; Department of Medicine, CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd., Hebei, China.
Yuan J; Department of Biostatistics, CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd., Hebei, China.
Ni S; Department of Biostatistics, CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd., Hebei, China.
Wang Y; GCP Center/ Institute of Drug Clinical Trials, West China Hospital of Sichuan University, Sichuan, China. Electronic address: wangy756@163.com.
Luo Z; GCP Center/ Institute of Drug Clinical Trials, West China Hospital of Sichuan University, Sichuan, China. Electronic address: luozhu720@163.com.

Eur J Pharm Sci ; 159: 105724, 2021 Apr 01.

Article em En | MEDLINE | ID: mdl-33482315

Assuntos

Transtorno Depressivo Maior; Administração Oral; Área Sob a Curva; Benzodioxóis; Transtorno Depressivo Maior/tratamento farmacológico; Relação Dose-Resposta a Droga; Método Duplo-Cego; Voluntários Saudáveis; Humanos; Propilaminas

Palavras-chave

Ammoxetine; First-in-human; Major depressive disorder; Pharmacokinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Revista: Eur J Pharm Sci Assunto da revista: FARMACIA / FARMACOLOGIA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Holanda

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