Severe injury-induced osteoporosis and skeletal muscle mineralization: Are these related complications?
Bone Rep
; 14: 100743, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33490313
ABSTRACT
Severely injured patients are beleaguered by complications during convalescence, such as dysregulated biomineralization. Paradoxically, severely injured patients experience the loss of bone (osteoporosis), resulting in diminished skeletal integrity and increased risk of fragility fractures; yet they also accrue mineralization in soft tissues, resulting in complications such as heterotopic ossification (HO). The pathophysiology leading to dysregulated biomineralization in severely injured patients is not well defined. It has been postulated that these pathologies are linked, such that mineralization is "transferred" from the bone to soft tissue compartments. The goal of this study was to determine if severe injury-induced osteoporosis and soft tissue calcification are temporally coincident following injury. Using a murine model of combined burn and skeletal muscle injury to model severe injury, it was determined that mice developed significant progressive bone loss, detectable as early as 3 days post injury, and marked soft tissue mineralization by 7 days after injury. The observed temporal concordance between the development of severe injury-induced osteoporosis and soft tissue mineralization indicates the plausibility that these complications share a common pathophysiology, though further experiments are required.
BMD, bone mineral density; BV/TV, bone volume/tissue volume; Biomineralization; Burn; CTX, cardiotoxin; DC, dystrophic calcification; DPI, days post injury; DXA, dual energy X-ray absorptiometry; Dystrophic calcification; H&E, hematoxylin and eosin; HO, heterotopic ossification; Heterotopic ossificaiton; Osteoporosis; STiCSS, soft tissue calcification scoring system; Severe injury; Severe injury-induced osteoporosis; Soft tissue mineralization; Trauma; µCT, microcomputed tomography
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Bone Rep
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos