A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-&#954;B Activation.

Castejón, María Luisa; Alarcón-de-la-Lastra, Catalina; Rosillo, María Ángeles; Montoya, Tatiana; Fernández-Bolaños, Jose G; González-Benjumea, Alejandro; Sánchez-Hidalgo, Marina

A New Peracetylated Oleuropein Derivative Ameliorates Joint Inflammation and Destruction in a Murine Collagen-Induced Arthritis Model via Activation of the Nrf-2/Ho-1 Antioxidant Pathway and Suppression of MAPKs and NF-κB Activation.

Castejón, María Luisa; Alarcón-de-la-Lastra, Catalina; Rosillo, María Ángeles; Montoya, Tatiana; Fernández-Bolaños, Jose G; González-Benjumea, Alejandro; Sánchez-Hidalgo, Marina.

Afiliação

Castejón ML; Department of Pharmacology, School of Pharmacy, University of Seville, 41012 Seville, Spain.
Alarcón-de-la-Lastra C; Department of Pharmacology, School of Pharmacy, University of Seville, 41012 Seville, Spain.
Rosillo MÁ; Department of Pharmacology, School of Pharmacy, University of Seville, 41012 Seville, Spain.
Montoya T; Department of Pharmacology, School of Pharmacy, University of Seville, 41012 Seville, Spain.
Fernández-Bolaños JG; Department of Organic Chemistry, School of Chemistry, University of Seville, 41012 Seville, Spain.
González-Benjumea A; Department of Organic Chemistry, School of Chemistry, University of Seville, 41012 Seville, Spain.
Sánchez-Hidalgo M; Department of Pharmacology, School of Pharmacy, University of Seville, 41012 Seville, Spain.

Nutrients ; 13(2)2021 Jan 22.

Article em En | MEDLINE | ID: mdl-33499113

Assuntos

Artrite Experimental/dietoterapia; Inflamassomos/efeitos dos fármacos; Glucosídeos Iridoides/farmacologia; Animais; Artrite Experimental/induzido quimicamente; Artrite Experimental/metabolismo; Suplementos Nutricionais; Modelos Animais de Doenças; Heme Oxigenase-1/metabolismo; Inflamassomos/metabolismo; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Metaloproteinase 3 da Matriz/metabolismo; Proteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos DBA; Fator 2 Relacionado a NF-E2/metabolismo; NF-kappa B/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

CIA; MAPK; NF-κB; Nrf2/HO1; arthritis; inflammation; oleuropein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Experimental / Glucosídeos Iridoides / Inflamassomos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Nutrients Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Espanha País de publicação: Suíça

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