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An update on the rod microglia variant in experimental and clinical brain injury and disease.
Giordano, Katherine R; Denman, Charlotte R; Dubisch, Phoebe S; Akhter, Murtaza; Lifshitz, Jonathan.
Afiliação
  • Giordano KR; BARROW Neurological Institute at Phoenix Children's Hospital, Phoenix, AZ, USA.
  • Denman CR; Department of Child Health, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.
  • Dubisch PS; Department of Child Health, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, USA.
  • Akhter M; Department of Biology and Biochemistry, University of Bath, Bath, UK.
  • Lifshitz J; Dubisch Scientific Illustration, Phoenix, AZ, USA.
Brain Commun ; 3(1): fcaa227, 2021.
Article em En | MEDLINE | ID: mdl-33501429
ABSTRACT
Contemporary microglia morphologies include ramified, activated and amoeboid, with the morphology of microglia considered highly coupled to the cellular function. Rod microglia are an additional activated microglia variant observed in the ageing, injured and diseased brain. Rod microglia were reported frequently in the early 1900s by neuropathologists in post-mortem cases of general paresis, Alzheimer's disease and encephalitis, and then remained largely ignored for almost 100 years. Recent reports have renewed interest in rod microglia, most notably after experimental traumatic brain injury. Rod microglia are formed by the narrowing of the soma and retraction of planar processes, which results in the appearance of an elongated, rod-shaped cell. Rod microglia are most commonly observed in the cortex, aligned perpendicular to the dural surface and adjacent to neuronal processes; in the hippocampus, they are aligned perpendicular to hippocampal layers. Furthermore, rod microglia form trains with one another, apical end to basal end. By replicating the process of sketching microscopic observation, rod microglia are re-defined by circumnutation around the long axis. In this update, we summarize the rod microglia variant in clinical and experimental literature and advocate for investigation into mechanisms of rod microglia origin and function.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Brain Commun Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: Brain Commun Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos