Development and validation of a simple and sensitive LC-MS/MS method for quantification of ampicillin and sulbactam in human plasma and its application to a clinical pharmacokinetic study.

Nalbant, Demet; Reeder, Joshua A; Li, Peizhi; O'Sullivan, Cormac T; Rogers, William K; An, Guohua

Nalbant, Demet; Reeder, Joshua A; Li, Peizhi; O'Sullivan, Cormac T; Rogers, William K; An, Guohua.

Afiliação

Nalbant D; Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, USA.
Reeder JA; Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, USA.
Li P; College of Pharmacy, University of Iowa, USA.
O'Sullivan CT; College of Nursing, University of Iowa Hospital and Clinics, USA.
Rogers WK; Department of Anesthesia, University of Minnesota Medical School, M Health Fairview, USA.
An G; Division of Pharmaceutics and Translational Therapeutics, College of Pharmacy, University of Iowa, USA. Electronic address: guohua-an@uiowa.edu.

J Pharm Biomed Anal ; 196: 113899, 2021 Mar 20.

Article em En | MEDLINE | ID: mdl-33508765

Assuntos

Preparações Farmacêuticas; Espectrometria de Massas em Tandem; Ampicilina; Cromatografia Líquida; Humanos; Reprodutibilidade dos Testes; Sulbactam

Palavras-chave

Ampicillin-sulbactam; Assay development and validation; Clinical pharmacokinetics study; Human plasma antibiotic redosing; LC/MS/MS

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Preparações Farmacêuticas / Espectrometria de Massas em Tandem Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: J Pharm Biomed Anal Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Reino Unido

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