The Role of the Microenvironment and Immune System in Regulating Stem Cell Fate in Cancer.
Trends Cancer
; 7(7): 624-634, 2021 07.
Article
em En
| MEDLINE
| ID: mdl-33509688
ABSTRACT
Despite gains in knowledge of the intrinsic signals governing cancer progression, effective clinical management of cancer remains a challenge. Drug resistance and relapse, pose the greatest barriers to cancer care, and are often driven by the co-option of stem cell programs by subpopulations of aggressive cancer cells. Here, we focus on the role of the microenvironment in the acquisition and/or maintenance of stem cell states in cancer in the context of resistance and metastasis. We further discuss the role of cancer stem cells in immune evasion through the course of metastasis, dormancy, and relapse. Understanding the niche in which cancer stem cells live and the signals that sustain them may lead to new strategies that target them by disrupting microenvironmental support.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células-Tronco Neoplásicas
/
Evasão Tumoral
/
Recidiva Local de Neoplasia
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Neoplasias
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Trends Cancer
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos