A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus <i>Via</i> Toll-Like Receptor 3 Signaling.

Enderes, Jana; Mallesh, Shilpashree; Schneider, Reiner; Hupa, Kristof J; Lysson, Mariola; Schneiker, Bianca; Händler, Kristian; Schlotmann, Balthasar; Günther, Patrick; Schultze, Joachim L; Kalff, Jörg C; Wehner, Sven

A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling.

Enderes, Jana; Mallesh, Shilpashree; Schneider, Reiner; Hupa, Kristof J; Lysson, Mariola; Schneiker, Bianca; Händler, Kristian; Schlotmann, Balthasar; Günther, Patrick; Schultze, Joachim L; Kalff, Jörg C; Wehner, Sven.

Afiliação

Enderes J; Department of Surgery, Division of Immune Pathophysiology, University Hospital Bonn, Bonn, Germany.
Mallesh S; Department of Surgery, Division of Immune Pathophysiology, University Hospital Bonn, Bonn, Germany.
Schneider R; Department of Surgery, Division of Immune Pathophysiology, University Hospital Bonn, Bonn, Germany.
Hupa KJ; Department of Surgery, Division of Immune Pathophysiology, University Hospital Bonn, Bonn, Germany.
Lysson M; Department of Surgery, Division of Immune Pathophysiology, University Hospital Bonn, Bonn, Germany.
Schneiker B; Department of Surgery, Division of Immune Pathophysiology, University Hospital Bonn, Bonn, Germany.
Händler K; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE), University of Bonn, Bonn, Germany.
Schlotmann B; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Günther P; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE), University of Bonn, Bonn, Germany.
Schultze JL; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.
Kalff JC; PRECISE Platform for Single Cell Genomics and Epigenomics, German Center for Neurodegenerative Diseases (DZNE), University of Bonn, Bonn, Germany.
Wehner S; Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany.

Front Immunol ; 11: 581111, 2020.

Article em En | MEDLINE | ID: mdl-33519804

Assuntos

Íleus/etiologia; Macrófagos/imunologia; Complicações Pós-Operatórias/etiologia; Receptor 3 Toll-Like/imunologia; Proteínas Adaptadoras de Transporte Vesicular/deficiência; Proteínas Adaptadoras de Transporte Vesicular/genética; Proteínas Adaptadoras de Transporte Vesicular/imunologia; Animais; Receptor 1 de Quimiocina CX3C/genética; Receptor 1 de Quimiocina CX3C/imunologia; Modelos Animais de Doenças; Feminino; Expressão Gênica; Íleus/imunologia; Íleus/patologia; Imunidade Inata; Macrófagos/classificação; Macrófagos/efeitos da radiação; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Camundongos Transgênicos; Plexo Mientérico/imunologia; Complicações Pós-Operatórias/imunologia; Complicações Pós-Operatórias/patologia; Tolerância a Radiação/imunologia; Receptor de Interferon alfa e beta/deficiência; Receptor de Interferon alfa e beta/genética; Receptor de Interferon alfa e beta/imunologia; Transdução de Sinais/imunologia; Receptor 3 Toll-Like/deficiência; Receptor 3 Toll-Like/genética; Quimeras de Transplante/imunologia

Palavras-chave

TLR3; TRIF; innate immune response; macrophages; postoperative ileus

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Pós-Operatórias / Íleus / Receptor 3 Toll-Like / Macrófagos Limite: Animals Idioma: En Revista: Front Immunol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Suíça

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