Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis.

McGregor, Lindsay; Földes, Tamás; Bui, Soi; Moulin, Martine; Coquelle, Nicolas; Blakeley, Matthew P; Rosta, Edina; Steiner, Roberto A

McGregor, Lindsay; Földes, Tamás; Bui, Soi; Moulin, Martine; Coquelle, Nicolas; Blakeley, Matthew P; Rosta, Edina; Steiner, Roberto A.

Afiliação

McGregor L; Randall Centre for Cell and Molecular Biophysics, King's College London, London SE1 1UL, United Kingdom.
Földes T; Large Scale Structures Group, Institut Laue-Langevin, 71 avenue des Martyrs, 38042 Cedex 9, Grenoble, France.
Bui S; Department of Chemistry, King's College London, London SE1 1DB, United Kingdom.
Moulin M; Department of Physics and Astronomy, University College, London WC1E 6BT, United Kingdom.
Coquelle N; Randall Centre for Cell and Molecular Biophysics, King's College London, London SE1 1UL, United Kingdom.
Blakeley MP; Life Sciences Group, Institut Laue-Langevin, 71 avenue des Martyrs, 38042 Cedex 9, Grenoble, France.
Rosta E; Large Scale Structures Group, Institut Laue-Langevin, 71 avenue des Martyrs, 38042 Cedex 9, Grenoble, France.
Steiner RA; Large Scale Structures Group, Institut Laue-Langevin, 71 avenue des Martyrs, 38042 Cedex 9, Grenoble, France.

IUCrJ ; 8(Pt 1): 46-59, 2021 Jan 01.

Article em En | MEDLINE | ID: mdl-33520242

Palavras-chave

biomolecular simulations; cofactor-independent oxidase; neutron/X-ray diffraction; protein perdeuteration; urate oxidase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Revista: IUCrJ Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Reino Unido

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