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Detection of singlet oxygen luminescence for experimental corneal rose bengal photodynamic antimicrobial therapy.
Peterson, Jeffrey C; Arrieta, Esdras; Ruggeri, Marco; Silgado, Juan D; Mintz, Keenan J; Weisson, Ernesto H; Leblanc, Roger M; Kochevar, Irene; Manns, Fabrice; Parel, Jean-Marie.
Afiliação
  • Peterson JC; Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Ave, Miami, FL 33136, USA.
  • Arrieta E; Department of Biomedical Engineering, University of Miami, 1251 Memorial Dr, Coral Gables, FL 33146, USA.
  • Ruggeri M; Miller School of Medicine, University of Miami, 1600 NW 10th Ave #1140, Miami, FL 33136, USA.
  • Silgado JD; petersonjeffreyc@gmail.com.
  • Mintz KJ; Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Ave, Miami, FL 33136, USA.
  • Weisson EH; Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Ave, Miami, FL 33136, USA.
  • Leblanc RM; Department of Biomedical Engineering, University of Miami, 1251 Memorial Dr, Coral Gables, FL 33146, USA.
  • Kochevar I; Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Ave, Miami, FL 33136, USA.
  • Manns F; Department of Chemistry, University of Miami, 1301 Memorial Dr, Coral Gables, FL 33146, USA.
  • Parel JM; Miller School of Medicine, University of Miami, 1600 NW 10th Ave #1140, Miami, FL 33136, USA.
Biomed Opt Express ; 12(1): 272-287, 2021 Jan 01.
Article em En | MEDLINE | ID: mdl-33520385
Rose bengal photodynamic antimicrobial therapy (RB-PDAT) treats corneal infection by activating rose bengal (RB) with green light to produce singlet oxygen (1O2). Singlet oxygen dosimetry can help optimize treatment parameters. We present a 1O2 dosimeter for detection of 1O2 generated during experimental RB-PDAT. The system uses a 520 nm laser and an InGaAs photoreceiver with bandpass filters to detect 1O2 luminescence during irradiation. The system was validated in RB solutions and ex vivo in human donor eyes. The results demonstrate the feasibility of 1O2 dosimetry in an experimental model of RB-PDAT in the cornea.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Biomed Opt Express Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Biomed Opt Express Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos