Persistent infection with a rotavirus vaccine strain in a child suffering from Severe Combined Immunodeficiency in Argentina.
Rev Argent Microbiol
; 53(3): 216-219, 2021.
Article
em En
| MEDLINE
| ID: mdl-33526290
ABSTRACT
Due to the high burden of disease associated with rotavirus, the massive vaccination in children before six months of age has been encouraged. Currently licensed oral live vaccines have shown low risk of associated adverse events in the general population. Noteworthy, postmarketing reports of severe gastroenteritis with persistent vaccine viral shedding in children with severe combined immunodeficiency (SCID) have led companies to include this inborn error of immunity as an additional contraindication. SCID is not usually screened in newborns from developing countries. Therefore, the administration of live attenuated vaccines represents the first contact of these patients with life-threatening pathogens. We describe a clinical case of an infant with SCID who suffered from persistent rotavirus symptomatic diarrhea after receiving the rotavirus oral vaccine and was found to be infected with the vaccine strain. This case attempts to contribute to the discussion of those diseases that need to be incorporated into a screening program since an early diagnosis permits clinicians to withhold live attenuated immunization.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Rotavirus
/
Imunodeficiência Combinada Severa
/
Rotavirus
/
Vacinas contra Rotavirus
Tipo de estudo:
Screening_studies
Limite:
Child
/
Humans
/
Infant
/
Newborn
País/Região como assunto:
America do sul
/
Argentina
Idioma:
En
Revista:
Rev Argent Microbiol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Argentina