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Purinergic Regulation of Endothelial Barrier Function.
Aslam, Muhammad; Gündüz, Dursun; Troidl, Christian; Heger, Jacqueline; Hamm, Christian W; Schulz, Rainer.
Afiliação
  • Aslam M; Experimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, Germany.
  • Gündüz D; Department of Cardiology, Kerckhoff Clinic GmbH, 61231 Bad Nauheim, Germany.
  • Troidl C; DZHK (German Centre for Cardiovascular Research), Partner Site Rhein-Main, 61231 Bad Nauheim, Germany.
  • Heger J; Experimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, Germany.
  • Hamm CW; Department of Cardiology and Angiology, Evangelisches Jung Stilling Krankenhaus GmbH, 57074 Siegen, Germany.
  • Schulz R; Experimental Cardiology, Department of Internal Medicine I, Justus Liebig University, Aulweg 129, 35392 Giessen, Germany.
Int J Mol Sci ; 22(3)2021 Jan 26.
Article em En | MEDLINE | ID: mdl-33530557
Increased vascular permeability is a hallmark of several cardiovascular anomalies, including ischaemia/reperfusion injury and inflammation. During both ischaemia/reperfusion and inflammation, massive amounts of various nucleotides, particularly adenosine 5'-triphosphate (ATP) and adenosine, are released that can induce a plethora of signalling pathways via activation of several purinergic receptors and may affect endothelial barrier properties. The nature of the effects on endothelial barrier function may depend on the prevalence and type of purinergic receptors activated in a particular tissue. In this review, we discuss the influence of the activation of various purinergic receptors and downstream signalling pathways on vascular permeability during pathological conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Receptores Purinérgicos / Endotélio Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Suíça

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Purinas / Receptores Purinérgicos / Endotélio Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Alemanha País de publicação: Suíça