Fine tuning the glycolytic flux ratio of EP-bifido pathway for mevalonate production by enhancing glucose-6-phosphate dehydrogenase (Zwf) and CRISPRi suppressing 6-phosphofructose kinase (PfkA) in Escherichia coli.

Li, Ying; Xian, He; Xu, Ya; Zhu, Yuan; Sun, Zhijie; Wang, Qian; Qi, Qingsheng

Li, Ying; Xian, He; Xu, Ya; Zhu, Yuan; Sun, Zhijie; Wang, Qian; Qi, Qingsheng.

Afiliação

Li Y; National Glycoengineering Research Center, State Key Laboratory of Microbial Technology, Shandong University, 72 Binhai Dadao, Qingdao, 266237, People's Republic of China.
Xian H; School of Chemistry and Molecular Biosciences, Faculty of Science, The University of Queensland, St Lucia, Australia.
Xu Y; National Glycoengineering Research Center, State Key Laboratory of Microbial Technology, Shandong University, 72 Binhai Dadao, Qingdao, 266237, People's Republic of China.
Zhu Y; National Glycoengineering Research Center, State Key Laboratory of Microbial Technology, Shandong University, 72 Binhai Dadao, Qingdao, 266237, People's Republic of China.
Sun Z; Marine Biology Institute, Shantou University, Shantou, 515063, People's Republic of China. zjsun@stu.edu.cn.
Wang Q; National Glycoengineering Research Center, State Key Laboratory of Microbial Technology, Shandong University, 72 Binhai Dadao, Qingdao, 266237, People's Republic of China. qiqi20011983@gmail.com.
Qi Q; National Glycoengineering Research Center, State Key Laboratory of Microbial Technology, Shandong University, 72 Binhai Dadao, Qingdao, 266237, People's Republic of China.

Microb Cell Fact ; 20(1): 32, 2021 Feb 02.

Article em En | MEDLINE | ID: mdl-33531004

Assuntos

Sistemas CRISPR-Cas/genética; Escherichia coli/enzimologia; Glucosefosfato Desidrogenase/metabolismo; Glicólise; Ácido Mevalônico/metabolismo; Fosfofrutoquinases/metabolismo; Trifosfato de Adenosina/metabolismo; Isótopos de Carbono; Regulação para Baixo; Metabolismo Energético; Fermentação; Análise do Fluxo Metabólico; NADP/metabolismo; Via de Pentose Fosfato; Regiões Promotoras Genéticas/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfofrutoquinases / Escherichia coli / Sistemas CRISPR-Cas / Glucosefosfato Desidrogenase / Glicólise / Ácido Mevalônico Idioma: En Revista: Microb Cell Fact Assunto da revista: BIOTECNOLOGIA / MICROBIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Reino Unido

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