Depletion of trace elements and acute ocular toxicity induced by desferrioxamine in patients with thalassaemia.
Arch Dis Child
; 63(3): 250-5, 1988 Mar.
Article
em En
| MEDLINE
| ID: mdl-3355204
ABSTRACT
High doses of intravenous desferrioxamine infused over a short period of time induce a large faecal and urinary iron excretion but also produce retinal abnormalities that are characterised by decreased amplitude on electroretinography and defective dark adaptation. This regimen also results in high faecal iron, zinc, and copper excretion, and reduced granulocyte zinc concentrations and alkaline phosphatase activity. The retinal abnormalities may be related to the zinc and copper deficiency and/or iron depletion 'per se' which interferes negatively with critical iron dependent enzymes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Retinianas
/
Talassemia
/
Zinco
/
Cobre
/
Desferroxamina
Limite:
Adolescent
/
Child
/
Humans
Idioma:
En
Revista:
Arch Dis Child
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Itália