Procyanidin B2 inhibits lipopolysaccharide­induced apoptosis by suppressing the Bcl­2/Bax and NF­&#954;B signalling pathways in human umbilical vein endothelial cells.

Song, Da-Qiang; Liu, Jiao; Wang, Fang; Li, Xiao-Fang; Liu, Ming-Hua; Zhang, Zhuo; Cao, Shou-Song; Jiang, Xian

Procyanidin B2 inhibits lipopolysaccharideinduced apoptosis by suppressing the Bcl2/Bax and NFκB signalling pathways in human umbilical vein endothelial cells.

Song, Da-Qiang; Liu, Jiao; Wang, Fang; Li, Xiao-Fang; Liu, Ming-Hua; Zhang, Zhuo; Cao, Shou-Song; Jiang, Xian.

Afiliação

Song DQ; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Liu J; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Wang F; Department of Pharmaceutical Analysis, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Li XF; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Liu MH; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Zhang Z; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Cao SS; Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.
Jiang X; Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China.

Mol Med Rep ; 23(4)2021 04.

Article em En | MEDLINE | ID: mdl-33576443

Assuntos

Apoptose/efeitos dos fármacos; Biflavonoides/farmacologia; Catequina/farmacologia; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Lipopolissacarídeos/farmacologia; NF-kappa B/metabolismo; Proantocianidinas/farmacologia; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Proteína X Associada a bcl-2/metabolismo; Sobrevivência Celular/efeitos dos fármacos; Células Cultivadas; Expressão Gênica/efeitos dos fármacos; Células Endoteliais da Veia Umbilical Humana/citologia; Células Endoteliais da Veia Umbilical Humana/metabolismo; Humanos; Interleucina-1beta/genética; Interleucina-1beta/metabolismo; Interleucina-6/genética; Interleucina-6/metabolismo; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Modelos Biológicos; Transdução de Sinais/efeitos dos fármacos; Fator de Necrose Tumoral alfa/genética; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

PB2; LPS; apoptosis; NFκB; cytokine; HUVECs

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catequina / Lipopolissacarídeos / NF-kappa B / Apoptose / Proteínas Proto-Oncogênicas c-bcl-2 / Biflavonoides / Proantocianidinas / Proteína X Associada a bcl-2 / Células Endoteliais da Veia Umbilical Humana Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Mol Med Rep Ano de publicação: 2021 Tipo de documento: Article País de publicação: Grécia

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