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EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction.
Zhao, Jing; Blayney, Alan; Liu, Xiaorong; Gandy, Lauren; Jin, Weihua; Yan, Lufeng; Ha, Jeung-Hoi; Canning, Ashley J; Connelly, Michael; Yang, Chao; Liu, Xinyue; Xiao, Yuanyuan; Cosgrove, Michael S; Solmaz, Sozanne R; Zhang, Yingkai; Ban, David; Chen, Jianhan; Loh, Stewart N; Wang, Chunyu.
Afiliação
  • Zhao J; College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
  • Blayney A; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
  • Liu X; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
  • Gandy L; Department of Chemistry, University of Massachusetts, Amherst, MA, USA.
  • Jin W; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
  • Yan L; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
  • Ha JH; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
  • Canning AJ; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
  • Connelly M; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
  • Yang C; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
  • Liu X; Department of Chemistry, New York University, New York, NY, USA.
  • Xiao Y; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
  • Cosgrove MS; Center for Biotechnology and Interdisciplinary Studies, Department of Chemistry and Chemical Biology, Department of Biological Sciences, Rensselaer Polytechnic Institute, Troy, NY, USA.
  • Solmaz SR; Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA.
  • Zhang Y; Department of Chemistry, State University of New York at Binghamton, Binghamton, NY, USA.
  • Ban D; Department of Chemistry, New York University, New York, NY, USA.
  • Chen J; NYU-ECNU Center for Computational Chemistry at NYU Shanghai, Shanghai, China.
  • Loh SN; Merck Research Laboratories, Mass Spectrometry and Biophysics, Kenilworth, NJ, USA.
  • Wang C; Department of Chemistry, University of Massachusetts, Amherst, MA, USA.
Nat Commun ; 12(1): 986, 2021 02 12.
Article em En | MEDLINE | ID: mdl-33579943

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catequina / Proteína Supressora de Tumor p53 / Apoptose / Proteínas Proto-Oncogênicas c-mdm2 Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Catequina / Proteína Supressora de Tumor p53 / Apoptose / Proteínas Proto-Oncogênicas c-mdm2 Limite: Humans Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido