N<sup>6</sup>-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles.

Wang, Xinyu; Liu, Chong; Zhang, Siwei; Yan, Huiwen; Zhang, Liwen; Jiang, Amin; Liu, Yong; Feng, Yun; Li, Di; Guo, Yuting; Hu, Xinyao; Lin, Yajing; Bu, Pengcheng; Li, Dong

N⁶-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles.

Wang, Xinyu; Liu, Chong; Zhang, Siwei; Yan, Huiwen; Zhang, Liwen; Jiang, Amin; Liu, Yong; Feng, Yun; Li, Di; Guo, Yuting; Hu, Xinyao; Lin, Yajing; Bu, Pengcheng; Li, Dong.

Afiliação

Wang X; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: wangxinyu@ibp.ac.cn.
Liu C; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Zhang S; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
Yan H; Key Laboratory of RNA Biology, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Zhang L; Key Laboratory of RNA Biology, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Jiang A; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China.
Liu Y; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Feng Y; Center for Biological Imaging, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Li D; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Guo Y; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Hu X; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Lin Y; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Bu P; Key Laboratory of RNA Biology, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Li D; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; Bioland Laboratory (Guangzhou Regenerativ

Dev Cell ; 56(5): 702-715.e8, 2021 03 08.

Article em En | MEDLINE | ID: mdl-33609462

Assuntos

Adenosina/análogos & derivados; Núcleo Celular/patologia; Neoplasias Esofágicas/patologia; Carcinoma de Células Escamosas do Esôfago/patologia; Regulação Neoplásica da Expressão Gênica; Neoplasias Pulmonares/secundário; RNA Longo não Codificante/genética; Adenosina/química; Animais; Apoptose; Biomarcadores Tumorais/genética; Núcleo Celular/genética; Núcleo Celular/metabolismo; Proliferação de Células; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/metabolismo; Carcinoma de Células Escamosas do Esôfago/genética; Carcinoma de Células Escamosas do Esôfago/metabolismo; Feminino; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Camundongos; Camundongos Endogâmicos NOD; Camundongos SCID; RNA Longo não Codificante/química; Células Tumorais Cultivadas; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

MALAT1 long noncoding RNA; RNA m(6)A modification; YTHDC1; metastasis; nuclear speckles

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Regulação Neoplásica da Expressão Gênica / Adenosina / Núcleo Celular / RNA Longo não Codificante / Carcinoma de Células Escamosas do Esôfago / Neoplasias Pulmonares Limite: Animals / Female / Humans Idioma: En Revista: Dev Cell Assunto da revista: EMBRIOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos

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