Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases.

Ngabonziza, Jean Claude S; Decroo, Tom; Maniliho, Rodrigue; Habimana, Yves M; Van Deun, Armand; de Jong, Bouke C

Ngabonziza, Jean Claude S; Decroo, Tom; Maniliho, Rodrigue; Habimana, Yves M; Van Deun, Armand; de Jong, Bouke C.

Afiliação

Ngabonziza JCS; National Reference Laboratory Division, Department of Biomedical Services, Rwanda Biomedical Centre, Kigali, Rwanda.
Decroo T; Mycobacteriology Unit, Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Maniliho R; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Habimana YM; Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.
Van Deun A; Research Foundation Flanders, Brussels, Belgium.
de Jong BC; Tuberculosis Laboratory, Kibagabaga Hospital, Kigali, Rwanda.

Open Forum Infect Dis ; 8(2): ofab034, 2021 Feb.

Article em En | MEDLINE | ID: mdl-33614819

ABSTRACT

ABSTRACT

We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.

Palavras-chave

Xpert MTB/RIF assay; active case finding; false detection of TB; rifampicin resistance

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies Idioma: En Revista: Open Forum Infect Dis Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Ruanda

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google