Retrospective evaluation of intranasal carcinomas in cats treated with external-beam radiotherapy: 42 cases.
J Vet Intern Med
; 35(2): 1018-1030, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33660305
ABSTRACT
BACKGROUND:
Little is known regarding the comparative efficacy of various irradiation strategies used to treat intranasal carcinomas (INC) in cats.OBJECTIVES:
Investigate outcomes and prognostic factors associated with survival for cats with INC. ANIMALS Forty-two cats with INC that underwent radiotherapy (RT).METHODS:
Single-arm retrospective study. Medical record review for cats with INC that underwent RT at 1 of 7 veterinary RT facilities. Irradiation protocols categorized as definitive-intent fractionated RT (FRT), definitive-intent stereotactic RT (SRT), and palliative-intent RT (PRT). Median overall survival time (OST) and disease progression-free survival (PFS; documented by advanced transverse imaging, or recurrence of symptoms) were calculated. Associations between tumor stage, RT protocol/intent, and adjunctive treatment usage and outcome were calculated.RESULTS:
Cats underwent SRT (N = 18), FRT (N = 8), and PRT (N = 16). In multivariate modeling, cats received definitive-intent treatment (DRT; FRT/SRT) had significantly longer median PFS (504 days, [95% confidence interval (CI) 428-580 days] vs PRT 198 days [95% CI 62-334 days]; p = 0.006) and median OST [721 days (95% CI 527-915 days) vs 284 days (95% CI 0-570 days); p = 0.001]). Cats that underwent second DRT course at time of recurrence lived significantly longer than cats that received 1 RT course (either DRT or PRT [median OST 824 days (95% CI 237-1410 days) vs 434 days (95% CI 277-591 days); p = .028]).CONCLUSION:
In cats with INC, DRT is associated with prolonged OST and PFS as compared to PRT. If tumor progression occurs, a second course of DRT should be considered.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Escamosas
/
Doenças do Gato
Tipo de estudo:
Guideline
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
J Vet Intern Med
Assunto da revista:
MEDICINA INTERNA
/
MEDICINA VETERINARIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos