[Killer immunoglobulin-like receptor and cancer]. / Estudio de casos y controles de los receptores de tipo KIR (killer inmunoglobulin-like receptor) en oncología.
An Pediatr (Engl Ed)
; 2021 Mar 01.
Article
em Es
| MEDLINE
| ID: mdl-33663964
INTRODUCTION: Natural killer (NK) cells play an important role in defense against tumor cells. The development and function of NK cells is governed by a dynamic balance between inhibition and activation of cell surface receptors, including KIR receptors. PATIENTS AND METHOD: A case-control study is carried out that compares a group of 46 children diagnosed with malignant diseases, the control group is made up of 82 healthy children. KIRs genes, haplotypes and ligands were determined and compared between groups. RESULTS: There are no differences in KIRs genes, KIRs haplotypes or in KIRs gene ligands between groups. However, when KIRS and ligands were jointly studied, k2DS1_C2 was significantly higher in the group of cancer children (pÌ=Ì0.016). CONCLUSIONS: Our results do not provide evidence of an association between pediatric cancer disease with genotypes and groups of genes KIRs. The k2DS1_C2 genotype could predispose to susceptibility to malignant processes in children.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Idioma:
Es
Revista:
An Pediatr (Engl Ed)
Ano de publicação:
2021
Tipo de documento:
Article
País de publicação:
Espanha