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Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial.
Paradela, Luciana S; Wall, Richard J; Carvalho, Sandra; Chemi, Giulia; Corpas-Lopez, Victoriano; Moynihan, Eoin; Bello, Davide; Patterson, Stephen; Güther, Maria Lucia S; Fairlamb, Alan H; Ferguson, Michael A J; Zuccotto, Fabio; Martin, Julio; Gilbert, Ian H; Wyllie, Susan.
Afiliação
  • Paradela LS; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Wall RJ; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Carvalho S; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Chemi G; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Corpas-Lopez V; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Moynihan E; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Bello D; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Patterson S; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Güther MLS; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Fairlamb AH; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Ferguson MAJ; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Zuccotto F; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Martin J; Global Health R&D, GlaxoSmithKline, Tres Cantos 28760, Spain.
  • Gilbert IH; Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
  • Wyllie S; Division of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK. Electronic address: s.wyllie@dundee.ac.uk.
Cell Chem Biol ; 28(5): 711-721.e8, 2021 05 20.
Article em En | MEDLINE | ID: mdl-33691122
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Leishmania donovani / Transferases Intramoleculares / Inibidores Enzimáticos / Antiprotozoários Idioma: En Revista: Cell Chem Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Leishmania donovani / Transferases Intramoleculares / Inibidores Enzimáticos / Antiprotozoários Idioma: En Revista: Cell Chem Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Reino Unido País de publicação: Estados Unidos