Microviscosity in lecithin liposomes: effect of nicotinic acid.
Arch Biochem Biophys
; 263(1): 117-20, 1988 May 15.
Article
em En
| MEDLINE
| ID: mdl-3369856
ABSTRACT
We have studied the effect of nicotinic acid, a drug commonly used as a vasodilatory agent and also for the treatment of hypercholesterolemia, on the fluidity profile of liposomes of egg lecithin and dipalmitoyl lecithin, using a fluorescent polarization probe. In both cases the drug decreases the membrane fluidity and for cholesterol-probed liposomes, it disrupts the "intermediate fluid condition" induced by cholesterol. The drug also affects the activation energy for diffusion in the hydrophobic region of the liposomes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilcolinas
/
Lipossomos
/
Niacina
Idioma:
En
Revista:
Arch Biochem Biophys
Ano de publicação:
1988
Tipo de documento:
Article
País de afiliação:
Índia