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A potent and selective PARP14 inhibitor decreases protumor macrophage gene expression and elicits inflammatory responses in tumor explants.
Schenkel, Laurie B; Molina, Jennifer R; Swinger, Kerren K; Abo, Ryan; Blackwell, Danielle J; Lu, Alvin Z; Cheung, Anne E; Church, W David; Kunii, Kaiko; Kuplast-Barr, Kristy G; Majer, Christina R; Minissale, Elena; Mo, Jan-Rung; Niepel, Mario; Reik, Christopher; Ren, Yue; Vasbinder, Melissa M; Wigle, Tim J; Richon, Victoria M; Keilhack, Heike; Kuntz, Kevin W.
Afiliação
  • Schenkel LB; Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; MOMA Therapeutics, Cambridge, MA 02142, USA.
  • Molina JR; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Swinger KK; Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; Xilio Therapeutics, Waltham, MA 02451, USA.
  • Abo R; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; Obsidian Therapeutics, Cambridge, MA 02138, USA.
  • Blackwell DJ; Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Lu AZ; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Cheung AE; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; A2Empowerment, Arlington, MA 02474, USA.
  • Church WD; Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Kunii K; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Kuplast-Barr KG; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Majer CR; Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Minissale E; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Mo JR; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Niepel M; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Reik C; Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; Bain & Company, Boston, MA 02116, USA.
  • Ren Y; Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Vasbinder MM; Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Wigle TJ; Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Richon VM; Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Keilhack H; Department of Biological Sciences, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA.
  • Kuntz KW; Department of Molecular Discovery, Ribon Therapeutics, Inc., Cambridge, MA 02140, USA. Electronic address: kkuntz@ribontx.com.
Cell Chem Biol ; 28(8): 1158-1168.e13, 2021 08 19.
Article em En | MEDLINE | ID: mdl-33705687
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-4 / Poli(ADP-Ribose) Polimerases / Inflamação / Neoplasias Renais / Macrófagos / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Chem Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interleucina-4 / Poli(ADP-Ribose) Polimerases / Inflamação / Neoplasias Renais / Macrófagos / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Cell Chem Biol Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos