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Graphene oxide prevents lateral amygdala dysfunctional synaptic plasticity and reverts long lasting anxiety behavior in rats.
Franceschi Biagioni, Audrey; Cellot, Giada; Pati, Elisa; Lozano, Neus; Ballesteros, Belén; Casani, Raffaele; Coimbra, Norberto Cysne; Kostarelos, Kostas; Ballerini, Laura.
Afiliação
  • Franceschi Biagioni A; Neuron Physiology and Technology Lab, International School for Advanced Studies (SISSA), Neuroscience, Via Bonomea 265, 34136, Trieste, Italy.
  • Cellot G; Neuron Physiology and Technology Lab, International School for Advanced Studies (SISSA), Neuroscience, Via Bonomea 265, 34136, Trieste, Italy.
  • Pati E; Neuron Physiology and Technology Lab, International School for Advanced Studies (SISSA), Neuroscience, Via Bonomea 265, 34136, Trieste, Italy.
  • Lozano N; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193, Barcelona, Spain.
  • Ballesteros B; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193, Barcelona, Spain.
  • Casani R; Neuron Physiology and Technology Lab, International School for Advanced Studies (SISSA), Neuroscience, Via Bonomea 265, 34136, Trieste, Italy.
  • Coimbra NC; Laboratory of Neuroanatomy & Neuropsychobiology, Department of Pharmacology, Ribeirão Preto Medical School of the University of São Paulo (FMRP-USP), Av. Bandeirantes 3900, 14049-900, Ribeirão Preto, SP, Brazil.
  • Kostarelos K; Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC and BIST, Campus UAB, Bellaterra, 08193, Barcelona, Spain; Nanomedicine Lab, National Graphene Institute and Faculty of Biology, Medicine & Health, The University of Manchester, AV Hill Building, Oxford Rd, Manchester, M13 9PL, Uni
  • Ballerini L; Neuron Physiology and Technology Lab, International School for Advanced Studies (SISSA), Neuroscience, Via Bonomea 265, 34136, Trieste, Italy. Electronic address: laura.ballerini@sissa.it.
Biomaterials ; 271: 120749, 2021 04.
Article em En | MEDLINE | ID: mdl-33714913
Engineered small graphene oxide (s-GO) sheets were previously shown to reversibly down-regulate glutamatergic synapses in the hippocampus of juvenile rats, disclosing an unexpected translational potential of these nanomaterials to target selective synapses in vivo. Synapses are anatomical specializations acting in the Central Nervous System (CNS) as functional interfaces among neurons. Dynamic changes in synaptic function, named synaptic plasticity, are crucial to learning and memory. More recently, pathological mechanisms involving dysfunctional synaptic plasticity were implicated in several brain diseases, from dementia to anxiety disorders. Hyper-excitability of glutamatergic neurons in the lateral nucleus of the amygdala complex (LA) is substantially involved in the storage of aversive memory induced by stressful events enabling post-traumatic stress disorder (PTSD). Here we translated in PTSD animal model the ability of s-GO, when stereotaxically administered to hamper LA glutamatergic transmission and to prevent the behavioral response featured in long-term aversive memory. We propose that s-GO, by interference with glutamatergic plasticity, impair LA-dependent memory retrieval related to PTSD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medo / Plasticidade Neuronal Limite: Animals Idioma: En Revista: Biomaterials Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália País de publicação: Holanda

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Medo / Plasticidade Neuronal Limite: Animals Idioma: En Revista: Biomaterials Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Itália País de publicação: Holanda