Prognostic Value of Combined Detection of Preoperative Albumin-to-Fibrinogen Ratio and Neutrophil-to-Lymphocyte Ratio in Operable Esophageal Squamous Cell Carcinoma Patients without Neoadjuvant Therapy.
Cancer Manag Res
; 13: 2359-2370, 2021.
Article
em En
| MEDLINE
| ID: mdl-33737833
BACKGROUND: We retrospectively analyzed the prognostic value of the albumin-to-fibrinogen ratio (AFR)-neutrophil-to-lymphocyte ratio (NLR) score, comprising preoperative AFR and NLR, in esophageal squamous cell carcinoma (ESCC) patients after radical resection. PATIENTS AND METHODS: Overall, 215 patients were included. The optimal cutoff value was determined using the receiver operating characteristic (ROC) curve. Based on a low AFR (<12.06) and high NLR (≥1.78), the AFR-NLR score was classified as 2 (both hematological abnormalities present), 1 (one abnormality present), or 0 (both abnormalities absent). Kaplan-Meier curves, Cox regression, and predicted nomogram were used to evaluate the prognostic value of the score. RESULTS: The prognostic value of the AFR-NLR score was better than that of AFR or NLR alone (P <0.05). Multivariate analysis showed that a high AFR-NLR score was an independent predictor of poor prognosis for overall survival (P <0.001). Additionally, in the nomogram including the AFR-NLR score, the net reclassification improvement index increased by 35.5% (P <0.001), and the integrated discrimination improvement index increased by 9.0% (P <0.001). The predictive accuracy of the established nomogram model was proved using Harrell's concordance index (0.811, 95% confidence interval: 0.765-0.856) and calibration curve. Notably, the decision analysis curve showed that the nomogram had a higher net benefit within most of the threshold probability range, indicating better clinical applicability. CONCLUSION: The AFR-NLR score is a useful predictor of the prognosis of ESCC patients after radical resection, and the nomogram established on the basis of this score has a good prognostic value.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
Cancer Manag Res
Ano de publicação:
2021
Tipo de documento:
Article
País de publicação:
Nova Zelândia