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Benserazide racemate and enantiomers induce fetal globin gene expression in vivo: Studies to guide clinical development for beta thalassemia and sickle cell disease.
Pace, Betty S; Perrine, Susan; Li, Biaoru; Makala, Levi; Xu, Hongyan; Takezaki, Mayuko; Wolf, Roman F; Wang, Amy; Xu, Xin; Huang, Junfeng; Alimardanov, Asaf; Tawa, Gregory J; Sangerman, Jose; Faller, Aidan; Zheng, Wei; Toney, London; Haugabook, Sharie J.
Afiliação
  • Pace BS; Department of Pediatrics, Augusta University, Augusta, GA 30912, USA.
  • Perrine S; Phoenicia BioSciences, Weston, MA 02493, USA; Department of Pharmacology and Experimental Therapeutics, Hemoglobinopathy Thalassemia Research Unit, Boston University School of Medicine, Boston, MA 02118, USA.
  • Li B; Department of Pediatrics, Augusta University, Augusta, GA 30912, USA.
  • Makala L; Department of Pediatrics, Augusta University, Augusta, GA 30912, USA.
  • Xu H; Department of Population Health Sciences, Augusta University, Augusta, GA 30912, USA.
  • Takezaki M; Department of Pediatrics, Augusta University, Augusta, GA 30912, USA.
  • Wolf RF; Department of Comparative Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
  • Wang A; Division of Preclinical Innovation, Therapeutics for Rare and Neglected Diseases (TRND) Program, Therapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
  • Xu X; Division of Preclinical Innovation, Therapeutics for Rare and Neglected Diseases (TRND) Program, Therapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
  • Huang J; Division of Preclinical Innovation, Therapeutics for Rare and Neglected Diseases (TRND) Program, Therapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
  • Alimardanov A; Division of Preclinical Innovation, Therapeutics for Rare and Neglected Diseases (TRND) Program, Therapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
  • Tawa GJ; Division of Preclinical Innovation, Therapeutics for Rare and Neglected Diseases (TRND) Program, Therapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
  • Sangerman J; Phoenicia BioSciences, Weston, MA 02493, USA; Department of Pharmacology and Experimental Therapeutics, Hemoglobinopathy Thalassemia Research Unit, Boston University School of Medicine, Boston, MA 02118, USA.
  • Faller A; Phoenicia BioSciences, Weston, MA 02493, USA; Department of Pharmacology and Experimental Therapeutics, Hemoglobinopathy Thalassemia Research Unit, Boston University School of Medicine, Boston, MA 02118, USA.
  • Zheng W; Division of Preclinical Innovation, Therapeutics for Rare and Neglected Diseases (TRND) Program, Therapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
  • Toney L; Division of Preclinical Innovation, Therapeutics for Rare and Neglected Diseases (TRND) Program, Therapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
  • Haugabook SJ; Division of Preclinical Innovation, Therapeutics for Rare and Neglected Diseases (TRND) Program, Therapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: sharie.haugabook@nih.gov.
Blood Cells Mol Dis ; 89: 102561, 2021 07.
Article em En | MEDLINE | ID: mdl-33744514
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Fetal / Dopaminérgicos / Benserazida / Regulação para Cima / Talassemia beta / Anemia Falciforme Limite: Animals / Humans Idioma: En Revista: Blood Cells Mol Dis Assunto da revista: HEMATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hemoglobina Fetal / Dopaminérgicos / Benserazida / Regulação para Cima / Talassemia beta / Anemia Falciforme Limite: Animals / Humans Idioma: En Revista: Blood Cells Mol Dis Assunto da revista: HEMATOLOGIA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos