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Custom-Made Antibiotic Cement-Coated Nail for the Treatment of Infected Bone Defect.
Wang, Guoliang; Luo, Wen; Zhou, Yong; Zhu, Zhenfeng; Zhao, Zihou; Liu, Shiyu; Li, Jing; Feng, Xuebin; Zheng, Yao; Liang, Jiahe; Yi, Jiangpu; Zhang, Yong; Zhang, Yunfei.
Afiliação
  • Wang G; Department of Orthopaedics, Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
  • Luo W; Department of Ultrasound, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710032, China.
  • Zhou Y; Department of Orthopaedics, Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
  • Zhu Z; Department of Orthopaedics, Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
  • Zhao Z; Department of Orthopaedics, Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
  • Liu S; Institute of Oral Tissue Engineering, Air Force Medical University, Xi'an, Shaanxi 710032, China.
  • Li J; Department of Plastic, Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
  • Feng X; Shaanxi Dongwang Technology Co. Ltd., Xi'an, Shaanxi 710075, China.
  • Zheng Y; Department of Pharmacy, Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
  • Liang J; Institute of 3D Printing, Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
  • Yi J; Institute of 3D Printing, Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
  • Zhang Y; Department of Orthopaedics, Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
  • Zhang Y; Department of Orthopaedics, Second Affiliated Hospital, Air Force Medical University, Xi'an, Shaanxi 710038, China.
Biomed Res Int ; 2021: 6693906, 2021.
Article em En | MEDLINE | ID: mdl-33748280
ABSTRACT

BACKGROUND:

Longbone infected bone defect remains a great challenge due to multiple surgeries, long-term treatment duration, and uncertain prognosis. Treatment principles include eradication/debridement, stabilization, and antibiotic administration. An antibiotic cement-coated nail has shown great prospects due to both local antibiotic elution and stabilization of bone defects. However, the current fabrication technique remains to be improved.

METHODS:

For the first time, we described a new method for custom-made cement-coated nail fabrication based on a 3D printing technique. A retrospective study of 19 consecutive patients with long bone infected bone defects from one medical center was conducted who met the inclusion and exclusion criteria from November 2016 to May 2020. The treatment involved thorough debridement, custom-made antibiotic cement-coated nail filling, and culture-specific systemic antibiotic treatment guided by a multidisciplinary team. Clinical and radiographic examinations (X-ray and CT scans) were used to evaluate bony union. Clinical and laboratory examinations were used to evaluate the infection control. The SF-36 score was used to evaluate patients' quality of life pre- and postoperatively.

RESULTS:

The mean follow-up was 98.8 weeks (ranging from 40 to 192). All cases achieved infection control, 3 cases achieved bone healing after one-stage operation, and 12 cases achieved bone healing after a two-stage bone graft procedure. At the last follow-up, none of the 19 patients had infection recurrence or 1 case had failure of the protective plate. The pre- and postoperative SF-36 score showed that there were statistical differences in all the 9 aspects.

CONCLUSIONS:

The precise custom-made antibiotic cement-coated intramedullary nail through the 3D printing technique used in this study is an effective strategy for the treatment of infected bone defects of long bone. This technique may help to increase the infection control rate and promote bone healing.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteomielite / Cimentos Ósseos / Pinos Ortopédicos / Placas Ósseas / Transplante Ósseo / Fixação Intramedular de Fraturas / Fraturas não Consolidadas / Antibacterianos Tipo de estudo: Observational_studies / Prognostic_studies Aspecto: Patient_preference Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Res Int Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteomielite / Cimentos Ósseos / Pinos Ortopédicos / Placas Ósseas / Transplante Ósseo / Fixação Intramedular de Fraturas / Fraturas não Consolidadas / Antibacterianos Tipo de estudo: Observational_studies / Prognostic_studies Aspecto: Patient_preference Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Res Int Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China