Andrographolide and its derivatives are effective compounds for gastrointestinal protection: a review.
Eur Rev Med Pharmacol Sci
; 25(5): 2367-2382, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33755974
OBJECTIVE: Andrographolide and its derivatives have many functions, such as anti-infection, anti-tumor, neuroprotection, and immune regulation. However, the gastrointestinal protective effects, especially gastrointestinal tumors, and inflammation-related diseases of andrographolide and its derivatives have not been well summarized and discussed. In this review, we aimed to summarize and discuss the pharmacological effects and underlying mechanisms of andrographolide and its derivatives in gastrointestinal protection, with a view to revealing more possibilities of andrographolide and its derivatives in gastrointestinal diseases prevention therapy. MATERIALS AND METHODS: The data in this review are searched and selected from PubMed with the keywords: Andrographolide and Andrographolide derivatives, and relevant data with gastrointestinal protection are extracted and discussed. RESULTS: Andrographolide and its derivatives have prophylactic and therapeutic effects in gastrointestinal disorders such as GU, gastric cancer, colorectal cancer, and inflammatory bowel disease. CONCLUSIONS: Andrographolide and its derivatives are effective compounds for gastrointestinal protection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Úlcera Gástrica
/
Helicobacter pylori
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Substâncias Protetoras
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Diterpenos
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Microbioma Gastrointestinal
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Antibacterianos
Limite:
Animals
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Humans
Idioma:
En
Revista:
Eur Rev Med Pharmacol Sci
Assunto da revista:
FARMACOLOGIA
/
TOXICOLOGIA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China
País de publicação:
Itália