Role of hypoxiainducible factor2α in lung cancer (Review).
Oncol Rep
; 45(5)2021 05.
Article
em En
| MEDLINE
| ID: mdl-33760175
ABSTRACT
Hypoxia is a common phenomenon during tumorigenesis and tumour development. In recent years, studies have found that hypoxiainducible factor (HIF)2α, also referred to as endothelial PAS domain protein1, plays an important role in tumours. HIF2α is an important oncogene and a critical prognostic indicator in nonsmall cell lung cancer. However, no unified conclusion can be drawn concerning HIF2α and small cell lung cancer, since few studies to date have focused on their association. An increasing number of studies have confirmed that HIF2α is involved in tumorigenesis, cell proliferation, angiogenesis, metastasis, drug resistance and radiotherapy failure in lung cancer. Of note, HIF2α plays a crucial role in lung cancer to maintain cancer cell stemness. Based on the importance of HIF2α in lung cancer, HIF2αtargeted therapy has been attracting increasing attention. Although this strategy currently appears to be promising in vitro, it has never been assessed as a therapy for lung cancer. The aim of the present review was to summarize the contribution of HIF2α to various aspects of lung cancer, as well as its potential as targeted therapy.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação Neoplásica da Expressão Gênica
/
Fatores de Transcrição Hélice-Alça-Hélice Básicos
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Carcinogênese
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Neoplasias Pulmonares
/
Neovascularização Patológica
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Oncol Rep
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2021
Tipo de documento:
Article