Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors.

Huang, Ming-Jie; Guo, Jia-Wen; Fu, Yun-Dong; You, Ya-Zhen; Xu, Wen-Yu; Song, Ting-Yu; Li, Ran; Chen, Zi-Tong; Huang, Li-Hua; Liu, Hong-Min

Huang, Ming-Jie; Guo, Jia-Wen; Fu, Yun-Dong; You, Ya-Zhen; Xu, Wen-Yu; Song, Ting-Yu; Li, Ran; Chen, Zi-Tong; Huang, Li-Hua; Liu, Hong-Min.

Afiliação

Huang MJ; Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
Guo JW; Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
Fu YD; Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
You YZ; Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
Xu WY; Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
Song TY; Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
Li R; Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
Chen ZT; Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China.
Huang LH; Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou 450001, China. Electronic address: hlh606@zzu.edu.cn.
Liu HM; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China. Electronic address: liuhm@zzu.edu.cn.

Bioorg Med Chem Lett ; 41: 127993, 2021 06 01.

Article em En | MEDLINE | ID: mdl-33775841

Assuntos

Descoberta de Drogas; Inibidores Enzimáticos/farmacologia; Histona Desmetilases/antagonistas & inibidores; Tranilcipromina/farmacologia; Linhagem Celular Tumoral; Relação Dose-Resposta a Droga; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/química; Histona Desmetilases/genética; Histona Desmetilases/metabolismo; Humanos; Estrutura Molecular; Relação Estrutura-Atividade; Tranilcipromina/análogos & derivados; Tranilcipromina/química

Palavras-chave

Gastric cancer; Histone demethylase; LSD1 inhibitor; Tranylcypromine

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tranilcipromina / Inibidores Enzimáticos / Descoberta de Drogas / Histona Desmetilases Limite: Humans Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: China País de publicação: Reino Unido

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