Innovative therapeutic strategy using prostaglandin I<sub>2</sub> agonist (ONO1301) combined with nano drug delivery system for pulmonary arterial hypertension.

Kanaya, Tomomitsu; Miyagawa, Shigeru; Kawamura, Takuji; Sakai, Yoshiki; Masada, Kenta; Nawa, Nobutoshi; Ishida, Hidekazu; Narita, Jun; Toda, Koichi; Kuratani, Toru; Sawa, Yoshiki

Innovative therapeutic strategy using prostaglandin I₂ agonist (ONO1301) combined with nano drug delivery system for pulmonary arterial hypertension.

Kanaya, Tomomitsu; Miyagawa, Shigeru; Kawamura, Takuji; Sakai, Yoshiki; Masada, Kenta; Nawa, Nobutoshi; Ishida, Hidekazu; Narita, Jun; Toda, Koichi; Kuratani, Toru; Sawa, Yoshiki.

Afiliação

Kanaya T; Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita, Osaka, 565-0871, Japan.
Miyagawa S; Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita, Osaka, 565-0871, Japan.
Kawamura T; Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita, Osaka, 565-0871, Japan.
Sakai Y; Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita, Osaka, 565-0871, Japan.
Masada K; Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita, Osaka, 565-0871, Japan.
Nawa N; Department of Pediatrics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Ishida H; Department of Pediatrics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Narita J; Department of Pediatrics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Toda K; Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita, Osaka, 565-0871, Japan.
Kuratani T; Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita, Osaka, 565-0871, Japan.
Sawa Y; Department of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka Suita, Osaka, 565-0871, Japan. sawa-p@surg1.med.osaka-u.ac.jp.

Sci Rep ; 11(1): 7292, 2021 03 31.

Article em En | MEDLINE | ID: mdl-33790393

Assuntos

Anti-Hipertensivos/uso terapêutico; Hipertensão Pulmonar/tratamento farmacológico; Nanocápsulas/química; Piridinas/uso terapêutico; Animais; Anti-Hipertensivos/administração & dosagem; Anti-Hipertensivos/farmacologia; Células Cultivadas; Epoprostenol/agonistas; Fibroblastos/efeitos dos fármacos; Fibroblastos/metabolismo; Fator de Crescimento de Hepatócito/genética; Fator de Crescimento de Hepatócito/metabolismo; Interleucinas/genética; Interleucinas/metabolismo; Masculino; Miócitos de Músculo Liso/efeitos dos fármacos; Miócitos de Músculo Liso/metabolismo; Fator de Crescimento Derivado de Plaquetas/genética; Fator de Crescimento Derivado de Plaquetas/metabolismo; Artéria Pulmonar/citologia; Piridinas/administração & dosagem; Piridinas/farmacologia; Ratos; Ratos Sprague-Dawley; Fator de Crescimento Transformador beta/genética; Fator de Crescimento Transformador beta/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Nanocápsulas / Hipertensão Pulmonar / Anti-Hipertensivos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Sci Rep Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão País de publicação: Reino Unido

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