Predicting the radiosensitivity of HPV-negative oropharyngeal squamous cell carcinoma using miR-130b.
Acta Otolaryngol
; 141(6): 640-645, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33794725
ABSTRACT
BACKGROUND:
Human papillomavirus (HPV)-negative oropharyngeal squamous cell carcinoma shows a higher rate of radiation resistance than HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). Radioresistant HPV-negative OPSCC is associated with unfavourable outcomes, but validated prognostic biomarkers remain lacking. AIMS/OBJECTIVES:
This study investigated biomarkers for radioresistant HPV-negative OPSCC. MATERIAL ANDMETHODS:
The Cancer Genome Atlas included miRNA sequence and mRNA sequence data from 528 HNSCC tumours. Of these, we used gene expression data for HPV-negative head and neck squamous cell carcinoma for which data were available on the effects of radiation, and compared miRNA sequence and mRNA sequence data between radioresistant and radiosensitive groups. We subsequently estimated downstream miRNA from the results. Finally, we validated miRNAs related to the outcomes of radiotherapy in our clinical cases.RESULTS:
Investigation of miRNA sequence revealed expression of miR-130b as the greatest difference between radiosensitive and radioresistant groups. We subsequently evaluated miR-130b expression in our clinical OPSCC cases. Values of miR-130b >5.372 (low expression), determined from receiver operating characteristic curve analyses, were associated with significantly longer progression-free survival and overall survival (p = .006, p = .04, respectively). CONCLUSIONS ANDSIGNIFICANCE:
Our results suggest that miR-130b has potential as a biomarker for the radiosensitivity of HPV-negative OPSCC.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tolerância a Radiação
/
Neoplasias Orofaríngeas
/
MicroRNAs
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Carcinoma de Células Escamosas de Cabeça e Pescoço
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Acta Otolaryngol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão