Central Role of T Follicular Helper Cells in Myasthenia Gravis.
Noro Psikiyatr Ars
; 58(1): 68-72, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-33795956
ABSTRACT
Myasthenia gravis (gMG) is a critical autoimmune disease, which has a serious impact on the life and survival of patients. Ocular Myasthenia Gravis (oMG) is often the initial manifestation of MG and has the potential to progress to gMG. However, to date no distinct mechanism has been found to clarify the pathogenesis of conversion from oMG to gMG. Recent studies have shown that the development and clinical progression of MG is closely associated with the abnormal function of follicular helper T (Tfh) cells. Thus, this article reviews the recently achieved research progress on the involvement of Tfh cells in MG immunopathogenesis and focuses on the role of Tfh cells and related-factors (IL-21, CXCL13, CXCR5, bcl-6 etc.) in germinal center formation and antibody production in MG immune response.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Noro Psikiyatr Ars
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China