Magnesium Influences Membrane Fusion during Myogenesis by Modulating Oxidative Stress in C2C12 Myoblasts.
Nutrients
; 13(4)2021 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-33804939
ABSTRACT
Magnesium (Mg) is essential to skeletal muscle where it plays a key role in myofiber relaxation. Although the importance of Mg in the mature skeletal muscle is well established, little is known about the role of Mg in myogenesis. We studied the effects of low and high extracellular Mg in C2C12 myogenic differentiation. Non-physiological Mg concentrations induce oxidative stress in myoblasts. The increase of reactive oxygen species, which occurs during the early phase of the differentiation process, inhibits myoblast membrane fusion, thus impairing myogenesis. Therefore, correct Mg homeostasis, also maintained through a correct dietary intake, is essential to assure the regenerative capacity of skeletal muscle fibers.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
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Desenvolvimento Muscular
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Mioblastos
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Magnésio
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Fusão de Membrana
Limite:
Animals
Idioma:
En
Revista:
Nutrients
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Itália