The Epidemiology of Meningitis in Infants under 90 Days of Age in a Large Pediatric Hospital.
Microorganisms
; 9(3)2021 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-33806478
ABSTRACT
BACKGROUND:
Meningitis is associated with substantial morbidity and mortality, particularly in the first three months of life.METHODS:
We conducted a retrospective review of patients <90 days of age with meningitis at Texas Children's Hospital from 2010-2017. Cases were confirmed using the National Healthcare Safety Network (NHSN) definition of meningitis.RESULTS:
Among 694 infants with meningitis, the most common etiology was viral (n = 351; 51%), primarily caused by enterovirus (n = 332; 95%). A quarter of cases were caused by bacterial infections (n = 190; 27%). The most common cause of bacterial meningitis was group B Streptococcus (GBS, n = 60; 32%), followed by Gram-negative rods other than E. coli (n = 40; 21%), and E. coli (n = 37; 19%). The majority of Gram-negative organisms (63%) were resistant to ampicillin, and nearly one-fourth of Gram-negative rods (23%) other than E. coli and 2 (6%) E. coli isolates were resistant to third-generation cephalosporins. Significant risk factors for bacterial meningitis were early preterm birth and the Black race.CONCLUSIONS:
Enteroviruses most commonly caused viral meningitis in infants; GBS was the most common bacterial cause despite universal screening and intrapartum prophylaxis. The emergence of MRSA and resistance to third-generation cephalosporins in Gram-negative bacterial meningitis challenges the options for empirical antimicrobial therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Risk_factors_studies
/
Screening_studies
Idioma:
En
Revista:
Microorganisms
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos