Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in <i>C. elegans</i>.

Sinnige, Tessa; Meisl, Georg; Michaels, Thomas C T; Vendruscolo, Michele; Knowles, Tuomas P J; Morimoto, Richard I

Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans.

Sinnige, Tessa; Meisl, Georg; Michaels, Thomas C T; Vendruscolo, Michele; Knowles, Tuomas P J; Morimoto, Richard I.

Afiliação

Sinnige T; Department of Molecular Biosciences, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208-3500; t.sinnige1@uu.nl r-morimoto@northwestern.edu.
Meisl G; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom.
Michaels TCT; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom.
Vendruscolo M; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom.
Knowles TPJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom.
Morimoto RI; Cavendish Laboratory, University of Cambridge, CB3 0HE Cambridge, United Kingdom.

Proc Natl Acad Sci U S A ; 118(11)2021 03 16.

Article em En | MEDLINE | ID: mdl-33836595

Assuntos

Peptídeos/metabolismo; Agregação Patológica de Proteínas/metabolismo; Amiloide/metabolismo; Animais; Caenorhabditis elegans; Cinética; Modelos Moleculares; Células Musculares/metabolismo; Agregados Proteicos

Palavras-chave

C. elegans; amyloid; chemical kinetics; polyglutamine; protein aggregation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Agregação Patológica de Proteínas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos

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