Variable immunogenicity of a vivax malaria blood-stage vaccine candidate.
Vaccine
; 39(19): 2668-2675, 2021 05 06.
Article
em En
| MEDLINE
| ID: mdl-33840564
ABSTRACT
Relapsing malaria caused by Plasmodium vivax is a neglected tropical disease and an important cause of malaria worldwide. Vaccines to prevent clinical disease and mosquito transmission of vivax malaria are needed to overcome the distinct challenges of this important public health problem. In this vaccine immunogenicity study in mice, we examined key variables of responses to a P. vivax Duffy binding protein vaccine, a leading candidate to prevent the disease-causing blood-stages. Significant sex-dependent differences were observed in B cell (CD80+) and T cell (CD8+) central memory subsets, resulting in significant differences in functional immunogenicity and durability of anti-DBP protective efficacy. These significant sex-dependent differences in inbred mice were in the CD73+CD80+ memory B cell, H2KhiCD38hi/lo, and effector memory subsets. This study highlights sex and immune genes as critical variables that can impact host responses to P. vivax antigens and must be taken into consideration when designing clinical vaccine studies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Malária Vivax
/
Vacinas Antimaláricas
/
Malária
Limite:
Animals
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Estados Unidos