Lack of collagen &#945;6(IV) chain in mice does not cause severe-to-profound hearing loss or cochlear malformation, a distinct phenotype from nonsyndromic hearing loss with COL4A6 missense mutation.

Tang, Shaoying; Yonezawa, Tomoko; Maeda, Yukihide; Ono, Mitsuaki; Maeba, Takahiro; Miyoshi, Toru; Momota, Ryusuke; Tomono, Yasuko; Oohashi, Toshitaka

Lack of collagen α6(IV) chain in mice does not cause severe-to-profound hearing loss or cochlear malformation, a distinct phenotype from nonsyndromic hearing loss with COL4A6 missense mutation.

Tang, Shaoying; Yonezawa, Tomoko; Maeda, Yukihide; Ono, Mitsuaki; Maeba, Takahiro; Miyoshi, Toru; Momota, Ryusuke; Tomono, Yasuko; Oohashi, Toshitaka.

Afiliação

Tang S; Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Yonezawa T; Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Maeda Y; Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Ono M; Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Maeba T; Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Miyoshi T; Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Momota R; Department of Human Morphology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Tomono Y; Division of Molecular and Cell Biology, Shigei Medical Research Institute, Okayama, Japan.
Oohashi T; Department of Molecular Biology and Biochemistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

PLoS One ; 16(4): e0249909, 2021.

Article em En | MEDLINE | ID: mdl-33848312

Assuntos

Cóclea/metabolismo; Colágeno Tipo IV/genética; Surdez/patologia; Animais; Limiar Auditivo; Cóclea/química; Cóclea/diagnóstico por imagem; Cóclea/patologia; Colágeno Tipo IV/deficiência; Surdez/congênito; Surdez/genética; Modelos Animais de Doenças; Humanos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Mutação de Sentido Incorreto; Fenótipo; Multimerização Proteica; Microtomografia por Raio-X

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cóclea / Colágeno Tipo IV / Surdez Limite: Animals / Humans / Male Idioma: En Revista: PLoS One Assunto da revista: CIENCIA / MEDICINA Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Japão País de publicação: Estados Unidos

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