BMI and risk of all-cause mortality in normotensive and hypertensive adults: the rural Chinese cohort study.
Public Health Nutr
; 24(17): 5805-5814, 2021 12.
Article
em En
| MEDLINE
| ID: mdl-33861189
ABSTRACT
OBJECTIVE:
The impact of baseline hypertension status on the BMI-mortality association is still unclear. We aimed to examine the moderation effect of hypertension on the BMI-mortality association using a rural Chinese cohort.DESIGN:
In this cohort study, we investigated the incident of mortality according to different BMI categories by hypertension status.SETTING:
Longitudinal population-based cohort.PARTICIPANTS:
17 262 adults ≥18 years were recruited from July to August of 2013 and July to August of 2014 from a rural area in China.RESULTS:
During a median 6-year follow-up, we recorded 1109 deaths (610 with and 499 without hypertension). In adjusted models, as compared with BMI 22-24 kg/m2, with BMI ≤ 18, 18-20, 20-22, 24-26, 26-28, 28-30 and >30 kg/m2, the hazard ratios for mortality in normotensive participants were 1·92 (95% CI 1·23, 3·00), 1·44 (95% CI 1·01, 2·05), 1·14 (95% CI 0·82, 1·58), 0·96 (95% CI 0·70, 1·31), 0·96 (95% CI 0·65, 1·43), 1·32 (95% CI 0·81, 2·14) and 1·32 (95% CI 0·74, 2·35), respectively, and in hypertensive participants were 1·85 (95% CI 1·08, 3·17), 1·67 (95% CI 1·17, 2·39), 1·29 (95% CI 0·95, 1·75), 1·20 (95% CI 0·91, 1·58), 1·10 (95% CI 0·83, 1·46), 1·10 (95% CI 0·80, 1·52) and 0·61 (95% CI 0·40, 0·94), respectively. The risk of mortality was lower in individuals with hypertension with overweight or obesity v. normal weight, especially in older hypertensives (≥60 years old). Sensitivity analyses gave consistent results for both normotensive and hypertensive participants.CONCLUSIONS:
Low BMI was significantly associated with increased risk of all-cause mortality regardless of hypertension status in rural Chinese adults, but high BMI decreased the mortality risk among individuals with hypertension, especially in older hypertensives.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hipertensão
Tipo de estudo:
Etiology_studies
/
Incidence_studies
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Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Humans
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Public Health Nutr
Assunto da revista:
CIENCIAS DA NUTRICAO
/
SAUDE PUBLICA
Ano de publicação:
2021
Tipo de documento:
Article