Does XIST safeguard against sex-biased human diseases?
Mol Cell
; 81(8): 1598-1600, 2021 04 15.
Article
em En
| MEDLINE
| ID: mdl-33861949
ABSTRACT
Yu et al. (2021) demonstrate that a subset of X-linked immune genes is repressed on the inactive X chromosome (Xi) in a manner dependent on XIST RNA in B cells, and derepression of these genes upon XIST depletion could bias differentiation of naive B cells and be involved in etiology of female-biased autoimmune diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Inativação do Cromossomo X
/
RNA Longo não Codificante
Limite:
Female
/
Humans
Idioma:
En
Revista:
Mol Cell
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2021
Tipo de documento:
Article