Added value of anxiolytic benzodiazepines in predictive models on severe delirium in patients with acute decompensated heart failure: A retrospective analysis.
PLoS One
; 16(4): e0250372, 2021.
Article
em En
| MEDLINE
| ID: mdl-33886657
ABSTRACT
BACKGROUND:
Delirium in patients with acute decompensated heart failure (ADHF) is associated with poor clinical outcomes. Although some medications have been reported as risk factors for delirium, their impact on patients with ADHF is still unclear. This study aimed to determine the association of specific medication use with delirium and their additive predictive value in models based on conventional risk factors. METHODS ANDRESULTS:
In this single-center, retrospective study, 650 patients treated for ADHF were included. Fifty-nine patients (9.1%) had delirium. In multivariate analysis, anxiolytic benzodiazepines [odds ratio (OR) 6.4, 95% confidence interval (CI) 2.8-15], mechanical ventilation or noninvasive positive pressure ventilation (OR 6.0, 95% CI 2.9-12), depression (OR 3.2, 95% CI 1.5-6.5), intensive care or high care unit admission (OR 2.9, 95% CI 1.5-5.6), male sex (OR 2.0, 95% CI 1-3.7), and age (OR 1.1, 95% CI 1-1.1) were independently associated with severe delirium. The predictive model that included anxiolytic benzodiazepines had a significantly better discriminatory ability for the incidence of severe delirium than the conventional model.CONCLUSIONS:
The use of anxiolytic benzodiazepines was independently correlated with severe delirium, and their use in models based on conventional risk factors had an additive value for predicting delirium in patients with ADHF.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ansiolíticos
/
Benzodiazepinas
/
Índice de Gravidade de Doença
/
Delírio
/
Insuficiência Cardíaca
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Japão