The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NF&#954;B transcripts to dampen antiviral innate immunity.

Xu, Jian; Cai, Yunhong; Ma, ZhenBang; Jiang, Bo; Liu, Wenxiao; Cheng, Jing; Guo, Nannan; Wang, Zishu; Sealy, Joshua E; Song, Cuiping; Wang, Xiaojia; Li, Yongqing

The RNA helicase DDX5 promotes viral infection via regulating N6-methyladenosine levels on the DHX58 and NFκB transcripts to dampen antiviral innate immunity.

Xu, Jian; Cai, Yunhong; Ma, ZhenBang; Jiang, Bo; Liu, Wenxiao; Cheng, Jing; Guo, Nannan; Wang, Zishu; Sealy, Joshua E; Song, Cuiping; Wang, Xiaojia; Li, Yongqing.

Afiliação

Xu J; Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agricultural and Forestry Sciences, Beijing, P. R. China.
Cai Y; Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agricultural and Forestry Sciences, Beijing, P. R. China.
Ma Z; College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, P. R. China.
Jiang B; Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agricultural and Forestry Sciences, Beijing, P. R. China.
Liu W; Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agricultural and Forestry Sciences, Beijing, P. R. China.
Cheng J; Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agricultural and Forestry Sciences, Beijing, P. R. China.
Guo N; Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agricultural and Forestry Sciences, Beijing, P. R. China.
Wang Z; College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi, P. R. China.
Sealy JE; The Pirbright Institute, Ash Rd, Pirbright, Woking, United Kingdom.
Song C; China Animal Health and Epidemiology Center, Qingdao, Shandong, P. R. China.
Wang X; College of Veterinary Medicine, China Agricultural University, Beijing, P. R. China.
Li Y; Institute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agricultural and Forestry Sciences, Beijing, P. R. China.

PLoS Pathog ; 17(4): e1009530, 2021 04.

Article em En | MEDLINE | ID: mdl-33909701

Assuntos

Adenosina/análogos & derivados; RNA Helicases DEAD-box/fisiologia; Evasão da Resposta Imune/genética; Estabilidade de RNA/genética; Viroses; Adenosina/metabolismo; Animais; Células Cultivadas; Embrião de Galinha; Cricetinae; RNA Helicases DEAD-box/genética; Células HEK293; Humanos; Imunidade Inata/genética; Camundongos; Camundongos Endogâmicos C57BL; NF-kappa B/genética; NF-kappa B/metabolismo; RNA Helicases/genética; RNA Helicases/metabolismo; RNA Mensageiro/metabolismo; Viroses/genética; Viroses/imunologia; Viroses/metabolismo; Replicação Viral/genética

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Viroses / Adenosina / Estabilidade de RNA / RNA Helicases DEAD-box / Evasão da Resposta Imune Limite: Animals / Humans Idioma: En Revista: PLoS Pathog Ano de publicação: 2021 Tipo de documento: Article País de publicação: Estados Unidos

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